Heike Grebin studied architecture in Weimar. From 1989, she was a member of the East Berlin graphic design studio grappa (since 2014 Troppo Design). From 2003 to 2025, she taught visual communication at the Hamburg University of Applied Sciences. She also taught during semesters abroad and in workshops, including at the Bezalel Academy for Design in Jerusalem.
She published photographs from her stays in Tel Aviv and Palermo in two books.